Related Experiment Video
Updated: May 13, 2026

A Flow Adhesion Assay to Study Leucocyte Recruitment to Human Hepatic Sinusoidal Endothelium Under Conditions of Shear Stress
Published on: March 21, 2014
Role of endothelial dysfunction and lymphocyte-platelet adhesion in the pathogenesis of bile peritonitis
E A Petrosyan1, O A Tereshenko, A A Botashev
1Department of Operative Surgery and Topographic Anatomy, Kuban State Medical University, Krasnodar, Russia. superego_ksmu@mail.ru
Abstract:
Bile peritonitis is associated with endotoxemia, endothelial dysfunction, and increased level of pro-inflammatory cytokines. Under these conditions, serum concentration of NO metabolites (nitrate/nitrite ratio) and NO production by platelets significantly increase in animals with bile peritonitis, which reflects the development of inflammatory process and its antithrombotic activity, respectively. At the same time, platelet adhesion to lymphocytes increased in animals with bile peritonitis. The observed effect was confirmed by a direct correlation between the adhesion activity of lymphocytes to platelets and the content of desquamated endotheliocytes. This phenomenon played a crucial role in the development of protective and reparative processes in the damaged surface of vessel wall.
Related Concept Videos
Cholecystitis
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Ulcerative Colitis
Cirrhosis II: Pathophysiology
Inflammatory Bowel Disease III: Crohn's Disease
