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Updated: May 13, 2026

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

Estimating cerebral microinfarct burden from autopsy samples.

M Brandon Westover¹, Matt T Bianchi, Chunhui Yang

¹Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, and Harvard Medical School, Boston, USA.

|March 15, 2013

Summary

This summary is machine-generated.

Even a few microinfarcts found in routine brain autopsies suggest a substantial whole-brain burden, potentially explaining neurologic dysfunction in small-vessel disease.

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Area of Science:

Neuropathology
Neuroscience
Gerontology

Background:

Cerebral microinfarcts are small lesions common in aging and dementia.
Assessing whole-brain microinfarct burden is challenging with routine autopsy sampling.

Purpose of the Study:

To develop a mathematical method for estimating total cerebral microinfarcts from limited autopsy tissue.
To quantify the potential whole-brain microinfarct burden in older adults.

Main Methods:

A mathematical model was created to extrapolate microinfarct counts from routine neuropathologic specimens.
Data from 648 participants in aging and dementia cohort studies were analyzed.

Main Results:

Estimating from 1-2 microinfarcts in routine samples suggested 552-1,104 total brain microinfarcts.
Validation in larger brain volumes yielded similar estimates, confirming the method's reliability.

Conclusions:

A few microinfarcts on routine sampling indicate a significant whole-brain burden.
This burden may contribute to neurologic dysfunction, particularly in small-vessel disease.
The estimation method may apply to other imaging-negative micropathologies.