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Updated: May 13, 2026
08:27
The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
Published on: July 25, 2011
Neuroprotection after cerebral ischemia.
Shobu Namura1, Hiroaki Ooboshi, Jialing Liu
1Neuroscience Institute, Department of Neurobiology, Morehouse School of Medicine, Atlanta, GA, USA.
Annals of the New York Academy of Sciences
|March 16, 2013
Summary
Cerebral ischemia, a leading cause of stroke, is now a treatable condition. Research focuses on understanding stroke mechanisms, identifying therapeutic targets, and optimizing treatment delivery for brain recovery.
Area of Science:
- Neurology
- Pathophysiology
- Neuroscience
Background:
- Cerebral ischemia, characterized by insufficient blood flow to the brain, is a primary cause of stroke.
- Stroke is a leading global cause of death and disability, with significant morbidity and mortality.
- Historically considered untreatable, cerebral ischemia and stroke are now recognized as potentially manageable conditions.
Framework:
- Investigating the intricate pathomechanisms of stroke.
- Characterizing the brain's endogenous mechanisms for injury response, survival, and repair.
- Identifying novel therapeutic targets for stroke intervention.
Implementation:
- Exploring potential drug targets for neuroprotection and neurorestoration.
- Evaluating cell-based therapies for brain repair after ischemic events.
- Optimizing the delivery of therapeutic agents to affected brain tissue.
Implications:
- Advancing the understanding of stroke pathophysiology.
- Developing innovative treatments for cerebral ischemia.
- Improving patient outcomes and reducing the burden of stroke worldwide.
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Overview
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.