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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

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Related Experiment Video

Updated: May 13, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Ayurvedic drug discovery.

Premalatha Balachandran1, Rajgopal Govindarajan

  • 1University of Mississippi, National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, MS 38677, USA +1 662 915 3463 ; +1 662 915 7062 ; prembala@olemiss.edu.

Expert Opinion on Drug Discovery
|March 16, 2013
PubMed
Summary

Ayurveda, a traditional Indian medicine, offers therapeutic benefits but requires modern adaptation. A reverse-pharmacology approach can unlock new drug discovery from Ayurvedic herbs and formulations.

Related Experiment Videos

Last Updated: May 13, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Area of Science:

  • Integrative Medicine
  • Pharmacology
  • Drug Discovery

Background:

  • Ayurveda is a widely practiced traditional Indian medicine system.
  • Modernizing Ayurvedic principles can yield novel therapeutic solutions for various disorders.
  • Existing evidence supports the efficacy of Ayurvedic herbs and formulations.

Purpose of the Study:

  • To explore the integration of Ayurvedic medicine with modern drug discovery.
  • To address challenges in implementing Ayurvedic principles in contemporary methodologies.
  • To highlight the potential of a reverse-pharmacology approach in Ayurvedic drug discovery.

Main Methods:

  • Reviewing existing literature on Ayurvedic medicine and drug discovery.
  • Proposing a reverse-pharmacology strategy for identifying therapeutic targets.
  • Emphasizing the need for clinical evaluation of safety, efficacy, and drug interactions.

Main Results:

  • Ayurvedic herbs and formulations have demonstrated significant therapeutic potential.
  • Several novel drug leads have been identified from Ayurvedic medicinal herbs.
  • A reverse-pharmacology approach can guide the discovery of new Ayurvedic drugs.

Conclusions:

  • Integrating Ayurveda with modern science offers unique therapeutic opportunities.
  • Further scientific exploration and technological adaptation are crucial for standardized Ayurvedic drug discovery.
  • Clinical validation of efficacy, safety, and drug interactions is essential for Ayurvedic formulations.