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Sample Preparation and Relative Quantitation using Reductive Methylation of Amines for Peptidomics Studies

Sample Preparation and Relative Quantitation using Reductive Methylation of Amines for Peptidomics Studies

Published on: November 4, 2021

Peptidomics in drug research.

E Clynen¹, G Baggerman, Sj Husson

¹Research Group Functional Genomics and Proteomics, K.U. Leuven, Naamsestraat 59, 3000 Leuven, Belgium +32 16 324260 ; +32 16 323902 ; Elke.Clynen@bio.kuleuven.be.

Expert Opinion on Drug Discovery

|March 16, 2013

Summary

Endogenous peptides show promise as therapeutics and drug targets. Advances in peptide biochemistry and peptidomics are accelerating the discovery of new diagnostic and therapeutic peptide leads.

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Sample Preparation and Relative Quantitation using Reductive Methylation of Amines for Peptidomics Studies

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Published on: December 1, 2020

Area of Science:

Biochemistry
Pharmacology
Proteomics

Background:

Endogenous peptides possess diverse functions, indicating significant potential as therapeutic agents or drug targets.
The pharmaceutical landscape is increasingly recognizing the value of peptides in drug development.

Purpose of the Study:

To review the current applications of peptides in medicine.
To explore how advancements in peptide biochemistry and peptidomics can identify novel diagnostic and therapeutic targets.

Main Methods:

Discussion of various peptidomics technologies.
Application of peptidomics in studying disease models, animal venoms, antimicrobial peptides, G-protein-coupled receptor ligands, and biomarkers.

Main Results:

Peptide-based drugs currently constitute a small but expanding segment of the pharmaceutical market.
Peptidomics methodology is a key driver for identifying new peptide drug candidates.

Conclusions:

The field of peptide therapeutics is poised for growth, driven by technological advancements.
Peptidomics offers a powerful approach to uncovering a wide array of new peptide-based drug leads for various medical applications.