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Updated: May 13, 2026

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
Published on: November 11, 2022
Risk assessment of atherosclerotic plaques based on global biomechanics
Simone Melchionna1, Giorgio Amati, Massimo Bernaschi
1IPCF - CNR, Consiglio Nazionale delle Ricerche, P.le A. Moro 2, 00185 Rome, Italy. simone.melchionna@gmail.com
Abstract:
We present the results of a computational study of the entire left coronary system simulated both at Newtonian level and at red blood cell resolution for a sizeable number of physiological conditions. We analyze the cardiovascular implications of stenotic plaques and show that the standard clinical criterion for surgical or percutaneous intervention, based on the fractional flow reserve (FFR), is significantly affected by system-dependent, local hemodynamic factors. A refined version, based on the new notion of local FFR response to stenotic growth, and accounting for statistical uncertainties due to flow heterogeneity, is suggested and illustrated.
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