Related Experiment Video
Updated: May 13, 2026
08:31
Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
High-throughput structural characterisation of therapeutic protein targets
Brian D Marsden1, Michael Sundstrom, Stefan Knapp
1The Structural Genomics Consortium, Botnar Research Centre, University of Oxford, Oxford, OX3 7LD, UK. michael.sundstrom@sgc.ox.ac.uk.
Expert Opinion on Drug Discovery
|March 19, 2013
Summary
High-throughput structural biology provides detailed insights into human and pathogen proteins. This structural data accelerates structure-guided drug discovery for targeted therapies and disease intervention.
Area of Science:
- Structural biology
- Drug discovery
- Biotechnology
Background:
- High-throughput structural biology projects focus on human proteins and pathogen proteins.
- Understanding protein structures is crucial for therapeutic development.
Purpose of the Study:
- To generate detailed structural insights of biologically relevant features in soluble or membrane protein families.
- To enable structure-guided drug discovery for pharmaceutical and biotechnology companies.
- To provide valuable structural descriptions for designing selective drugs and bioactive compounds.
Main Methods:
- High-throughput structural biology techniques.
- Structural analysis of protein families.
- Development of reagents and methodologies for structural studies.
Main Results:
- Detailed structural insights into therapeutically relevant protein families.
- Generation of reagents, methodologies, and technologies for structural biology.
- Identification of small molecules that selectively bind to therapeutic targets.
Conclusions:
- High-throughput structural biology is essential for advancing structure-guided drug discovery.
- Structural data facilitates the design of selective drugs targeting protein families.
- This approach yields valuable tools and insights for disease intervention.
