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Updated: May 13, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Mitochondrial function in sepsis.

Victor Jeger¹, Siamak Djafarzadeh, Stephan M Jakob

¹Department of Intensive Care Medicine, University Hospital Inselspital and University of Bern, Bern, Switzerland.

European Journal of Clinical Investigation

|March 19, 2013

Summary

This summary is machine-generated.

Mitochondrial dysfunction in sepsis is highly variable and not consistently proven as the cause of multiple organ failure. Further research is needed, especially in older patients with comorbidities.

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High-resolution Respirometry to Assess Mitochondrial Function in Permeabilized and Intact Cells

High-resolution Respirometry to Assess Mitochondrial Function in Permeabilized and Intact Cells

Published on: February 8, 2017

Area of Science:

Critical Care Medicine
Mitochondrial Biology
Sepsis Pathophysiology

Background:

The role of mitochondrial dysfunction in sepsis-induced multiple organ dysfunction and failure remains debated.
This review critically examines existing evidence on mitochondrial function during sepsis.

Purpose of the Study:

To evaluate the evidence for impaired mitochondrial function in the context of sepsis.
To synthesize findings from experimental animal models and clinical studies.

Main Methods:

Focused review of original studies on mitochondrial function in experimental sepsis (rodents, pigs) and human sepsis.
Exclusion of in vitro studies on isolated cells/tissues.
Literature search of PubMed from 1964 to July 2012.

Main Results:

No consistent pattern of sepsis-related mitochondrial dysfunction was observed across species.
High variability in mitochondrial function was noted, even in control conditions and across different organs.
Discrepancies in findings may stem from diverse sepsis models, experimental durations, and measurement techniques.

Conclusions:

Mitochondrial function in sepsis is highly variable, organ-specific, and dynamic.
Current data, primarily from young, healthy animals, do not support mitochondrial dysfunction as a universal cause of multiple organ failure in sepsis.
Future studies should investigate mitochondrial function in older patients and those with comorbidities.