Related Experiment Video
Updated: May 13, 2026

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene
Published on: December 31, 2014
Excellence in cell signaling research recognized with major new award
1Biological Systems Architecture Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK. stephan.feller@imm.ox.ac.uk.
Abstract:
The newly installed Life Sciences Breakthrough Prize (http://www.breakthroughprizeinlifesciences.org/), which comes with more than double the financial reward of the Nobel Prize, has been awarded to several world-leaders in the field of cancer-related cell signaling and therapy research: Lewis C. Cantley (PI3 kinase), Hans Clevers (Wnt signaling), Charles L. Sawyers (signaling-targeted cancer therapy), Bert Vogelstein (colorectal cancer signaling) and Robert Weinberg (Ras & other cancer-relevant genes). They have all made remarkable contributions to our understanding of cell communication and malignancies over the last decades. Needless to say that virtually all other awardees of the 11 scientists honored in 2013 have also, in one way or another, touched upon signaling molecules, highlighting the fundamental interdisciplinarity and significance of signal transduction for living cells in general. For example, Shinya Yamanaka's exciting work was built on the four transcriptional signaling proteins, Oct3/4, Sox2, Klf4 and c-Myc.
Related Concept Videos
Diversity in Cell Signaling Responses
Graded and Abrupt Responses
Some signaling systems generate...
What is Cell Signaling?
What is Cell Signaling?
Overview of Cell Signaling
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Overview of Cell Signaling
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cell-surface Signaling
