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Published on: February 10, 2020
Progress on materials and scaffold fabrications applied to esophageal tissue engineering
Qiuxiang Shen1, Peina Shi, Mongna Gao
1School of Medicine, Ningbo University, Ningbo 315211, China.
Summary
Esophageal tissue engineering offers a promising alternative to traditional therapies for diseases like atresia and carcinoma. This review examines current scaffold materials and fabrication methods for developing functional esophageal tissue replacements.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Gastroenterology
Background:
- Rising mortality from esophageal diseases necessitates advanced treatments.
- Current therapies (surgery, radiotherapy, chemotherapy) show limited efficacy.
- Tissue-engineered esophagus presents a potential future therapeutic solution.
Purpose of the Study:
- To review current materials used in esophageal tissue engineering scaffolds.
- To examine various scaffold fabrication methods in esophageal tissue engineering.
- To provide an overview of the state of research in esophageal tissue engineering.
Main Methods:
- Literature review of published research on esophageal tissue engineering.
- Analysis of scaffold materials (e.g., natural polymers, synthetic polymers).
- Evaluation of fabrication techniques (e.g., electrospinning, 3D printing).
Main Results:
- Scaffold properties are critical for successful esophageal tissue regeneration.
- Diverse biomaterials are being explored for scaffold development.
- Various fabrication techniques offer distinct advantages for creating esophageal scaffolds.
Conclusions:
- Esophageal tissue engineering is an emerging field with significant therapeutic potential.
- Further research into optimal scaffolds and fabrication is crucial for clinical translation.
- Advancements in biomaterials and engineering techniques are key to developing functional esophageal substitutes.
