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Related Concept Videos

Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...

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Related Experiment Video

Updated: May 13, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

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Inhaled proteins: challenges and perspectives.

Flore Depreter1, Gabrielle Pilcer, Karim Amighi

  • 1Laboratory of Pharmaceutics and Biopharmaceutics, Université Libre de Bruxelles, Belgium.

International Journal of Pharmaceutics
|March 19, 2013
PubMed
Summary

Pulmonary delivery of therapeutic proteins offers a non-invasive alternative to injections. Formulating these biologics for inhalation requires overcoming challenges like degradation and lung clearance for effective topical or systemic treatments.

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Intratracheal Administration of Dry Powder Formulation in Mice
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Intratracheal Administration of Dry Powder Formulation in Mice

Published on: July 25, 2020

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Last Updated: May 13, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Intratracheal Administration of Dry Powder Formulation in Mice
07:55

Intratracheal Administration of Dry Powder Formulation in Mice

Published on: July 25, 2020

Area of Science:

  • Biochemical Engineering
  • Pharmaceutical Sciences
  • Pulmonary Drug Delivery

Background:

  • Therapeutic biologics are gaining importance due to advancements in biochemical engineering and disease understanding.
  • Pulmonary delivery presents a non-invasive alternative to parenteral administration for both topical lung treatments and systemic therapies.
  • Challenges include formulation strategies to prevent protein degradation, manage inter-particle interactions, and evade lung clearance mechanisms.

Purpose of the Study:

  • To review the primary challenges in formulating proteins for inhalation.
  • To discuss potential strategies for overcoming these formulation hurdles.
  • To highlight dry formulations, drying techniques, stabilizing excipients, and clinical developments in inhaled protein therapeutics.

Main Methods:

  • Literature review focusing on formulation strategies for inhaled proteins.
  • Analysis of challenges related to protein stability, delivery, and lung physiology.
  • Examination of dry powder formulations, including preparation methods and excipients.
  • Overview of current commercial products and clinical trials for inhaled protein therapies.

Main Results:

  • Effective pulmonary protein delivery requires overcoming significant formulation and physiological barriers.
  • Dry powder formulations demonstrate particular success in stabilizing proteins for inhalation.
  • Various drying techniques and stabilizing excipients are crucial for maintaining protein integrity and biological activity.
  • Clinical development is progressing for both topical and systemic applications of inhaled proteins.

Conclusions:

  • Pulmonary delivery of therapeutic proteins is a promising, non-invasive route requiring specialized formulation approaches.
  • Dry powder formulations, optimized through specific drying techniques and excipients, are key to successful inhaled protein therapeutics.
  • Continued research and clinical development are essential for realizing the full potential of inhaled proteins for various diseases.