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[Extracorporeal xenospleen perfusion in vial-bacterial pneumonia in children]
Insights
Extracorporeal perfusion of xenospleen improved oxygen saturation and hemodynamics in critically ill children with severe pneumonia. Clinical and radiological improvements were observed within 14 days, allowing patients to transfer to a standard unit.
Area of Science:
- Pediatric Critical Care Medicine
- Xenotransplantation
- Respiratory Medicine
Background:
- Acute multisegmental pneumonia poses a significant threat to critically ill children.
- Conventional treatments may not always suffice for severe cases, necessitating novel therapeutic approaches.
Purpose of the Study:
- To evaluate the efficacy of extracorporeal perfusion of xenospleen in managing critically ill children with acute multisegmental pneumonia.
Main Methods:
- Extracorporeal perfusion of a xenospleen was administered to 11 critically ill children.
- Hemodynamic, immune status, and toxemia markers were monitored.
- Clinical, laboratory, and functional indices were assessed post-perfusion.
- Radiological findings were used to track pulmonary infiltration.
Main Results:
- Within 24 hours, patients showed increased blood oxygen saturation, optimized hemodynamics, and improved immune status, with reduced toxemia.
- Clinical and laboratory parameters stabilized between days 4-7 post-perfusion.
- Complete resolution of pulmonary infiltrations was observed radiologically 10-14 days after treatment.
Conclusions:
- Extracorporeal xenospleen perfusion is a promising therapeutic strategy for severe pediatric pneumonia.
- This method rapidly improves respiratory and hemodynamic function.
- It facilitates timely recovery and transfer of patients from intensive care.
Abstract:
Extracorporeal perfusion of xenospleen was used in the management of 11 critically ill children with acute multisegmental pneumonia. The first 24 h were characterized by progressive mounting in blood O2 saturation, optimization of hemodynamics and immune status, decrease of toxemia. On days 4-7 after perfusion stabilization of clinical, laboratory and functional indexes was observed. Radiological findings of pulmonary infiltration disappeared 10-14 days after sorption and all the patients were transferred to a somatic unit.