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Effect of thermal stress on MICA/B induction in a human liposarcoma cell line
Shirin Farjadian1, Shahrzad Rahimifar, Nasrollah Erfani
1Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran, farjadsh@sums.ac.ir.
Background:
A possible mechanism by which hyperthermia enhances tumor immunogenicity is the induction of NKG2D ligands on tumor cells. Although the expression of MHC class I chain-related protein A and B (MICA/B) has previously been reported in different carcinomas, there is no information about MICA/B expression in liposarcomas.
Objective:
To investigate MICA/B induction in a human liposarcoma cell line (SW-872) after thermotherapy.
Methods:
SW-872 and HeLa cell lines were subjected to thermal stress for 1 h at 42, 44 and 46C, and after 2, 4 and 6 h of incubation at 37C, MICA/B expression was assessed at the mRNA and protein levels.
Results:
Despite high levels of MICA/B transcripts in SW-872 cells at baseline, the expression of these genes decreased significantly at both the mRNA and protein levels after almost all thermal treatments.
Conclusion:
Our data conclude that thermotherapy under 42-46 C had no effect on MICA/B induction on SW-872 liposarcoma cell line but the effects of fever-range temperatures remain to be tested on this cell line.
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