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Updated: May 13, 2026
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
Increased IL-17A but decreased IL-27 serum levels in patients with multiple sclerosis
Zohreh Babaloo1, Reza Khajir Yeganeh, Mehdi Farhoodi
1Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, zbabaloo@tbzmed.ac.ir.
Background:
Effector CD4+ T cell subsets play an important role in Multiple Sclerosis (MS). Interleukin-27 (IL-27) suppresses Th (Th1, Th2 and Th17) cells and dampens autoimmunity and tissue inflammation by promoting the generation of Type 1 regulatory T cells (Tr1).
Objective:
To identify the relative levels of IL-27 and IL-17A in MS disease.
Method:
In a case-control study, venous blood was collected from forty MS patients and forty-three healthy subjects as control group. Serum levels of IL-27 and IL-17A were measured by ELISA method.
Results:
A significant difference between serum IL-17A concentration in patients (120.68 ± 209.85 pg/ml) and control group (67.26 ± 117.76 pg/ml, p=0.016) was found. Serum IL-27 levels of the MS patients (159.7 ± 581.4 pg/ml) were significantly lower than control subjects (180.35 ± 507.84 pg/ml, p=0.001).
Conclusion:
Our findings show decreased levels of IL-27 against increasing IL-17A levels in patients group which may suggest a suppressive role of IL-27 on inflammatory process of MS.
