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Chromhidrosis: a rare diagnosis requiring clinicopathologic correlation
Ange Wang1, Ashley Wysong, Kristin M Nord
1*Department of Dermatology, Stanford University School of Medicine, Stanford, CA; †Department of Dermatology, Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA; and ‡Department of Pathology, Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA.
The American Journal of Dermatopathology
|March 19, 2013
Summary
Chromhidrosis, a rare disorder causing colored sweat, is detailed in this case of a man with black cheek secretions. This report highlights a unique presentation of this condition in adult males.
Area of Science:
- Dermatology
- Histopathology
- Rare Diseases
Background:
- Chromhidrosis is a rare disorder characterized by colored sweat secretions.
- It typically affects the malar cheeks, axilla, or areolar regions.
- Histological findings include ectopic apocrine glands and lipofuscin pigments.
Observation:
- This case report details a 26-year-old man with a 2-3 year history of black secretions on his malar cheeks.
- Secretions were noted during exertion or when squeezing the cheeks.
- A biopsy confirmed histopathologic features consistent with chromhidrosis.
Findings:
- The patient presented with bilateral malar cheek black secretions.
- Histopathology confirmed chromhidrosis via H&E staining and UV fluorescence.
- This is the second reported case of chromhidrosis in an adult male.
Implications:
- This case represents the first report of an adult male with black malar cheek secretions due to chromhidrosis.
- It expands the known clinical spectrum of chromhidrosis.
- Further research into the specific mechanisms and triggers of chromhidrosis in males is warranted.
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