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Updated: May 13, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
Published on: April 16, 2012
Immunology of aging and cancer development
Tamas Fulop1, Anis Larbi, Rami Kotb
1Research Center on Aging, Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada. tamas.fulop@usherbrooke.ca
Abstract:
The incidence and prevalence of most cancers increase with age. The immune system is a unique mechanism of defense against pathogens and possibly cancers, however there is a body of evidence that the immune system of the aged is eroded, a phenomenon termed immunosenescence. Each arm of the immune system, innate and adaptive, is altered with aging, contributing to increased tumorigenesis. Related to immunosenescence, a low-grade inflammation also develops with aging contributing also to increase carcinogenesis. Understanding the contribution of immunosenescence to cancer development and progression may lead to better interventions in the elderly.
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