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Structures of paralytic acylpolyamines from the spider Agelenopsis aperta
G B Quistad1, S Suwanrumpha, M A Jarema
1Sandoz Crop Protection Corporation, Palo Alto, California 94304.
Biochemical and Biophysical Research Communications
|May 31, 1990
Abstract:
The structures are given for five paralytic acylpolyamines from the venom of the funnel web spider, Agelenopsis aperta. The acyl moieties are derived from (3-indolyl)acetic acid, (4-hydroxy-3-indolyl)acetic acid, and 4-hydroxybenzoic acid. The polyamine portions of the toxins are novel. Three toxins (AG489, AG505, and AG452) contain 1, 5, 9, 13, 18, 22-hexaazadocosane which is unique as a natural polyamine because of its length and hydroxylation at the 5-aza position. The polyamine portions of two other alpha-agatoxins (AG488 and AG504) are unusual also, containing guanidinooxy moieties.