Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Enhanced Elimination of Poison

Enhanced Elimination of Poison

Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...

Hepatic Drug Excretion: Enterohepatic Cycling

Hepatic Drug Excretion: Enterohepatic Cycling

Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...

Ion Exchange

Ion Exchange

Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or basic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A full thickness in vitro model of human skin for the penetration of highly toxic VX and the evaluation of different decontaminants.

Toxicology letters·2026

Same author

Next-generation broad-spectrum reactivators for effective countermeasure against organophosphorus poisoning.

Archives of toxicology·2026

Same author

A three-dimensional, bioartificial human skin equivalent as an innovative technology for studying the decontamination of the nerve agent VX.

Chemico-biological interactions·2026

Same author

Keratin adducts in human hair prove exposure to sulfur mustard in a real case of poisoning and indicate exposure to sesquimustard and O-lost in vitro.

Archives of toxicology·2026

Same author

Toxic Tear Gas 2-Chloroacetophenone (CN) Forms Adducts With Endogenous Plasma Thiols In Vitro Valuable as Biomarkers of Exposure.

Drug testing and analysis·2025

Same author

Approaches to the treatment of nerve agent poisoning with oximes - from experimental studies to the intensive care unit.

Clinical toxicology (Philadelphia, Pa.)·2025

Search research articles

Related Experiment Video

Updated: May 13, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Tabun scavengers based on hydroxamic acid containing cyclodextrins.

Florian Brandhuber¹, Michael Zengerle, Luzian Porwol

¹Institut für Pharmakologie und Toxikologie der Bundeswehr, Neuherbergstraße 11, D-80937 München, Germany.

Chemical Communications (Cambridge, England)

|March 19, 2013

Summary

New cyclodextrin compounds effectively neutralize the nerve agent tabun. These novel agents show rapid detoxification, offering a promising avenue for chemical threat mitigation and agent decontamination strategies.

More Related Videos

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Published on: September 5, 2018

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

Related Experiment Videos

Last Updated: May 13, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Published on: September 5, 2018

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

Published on: September 19, 2022

Area of Science:

Organic Chemistry
Biochemistry
Toxicology

Background:

Tabun is a highly toxic organophosphate nerve agent.
Development of effective antidotes and decontamination agents is crucial for public safety and military defense.
Cyclodextrins offer a versatile scaffold for designing novel therapeutic and detoxification agents.

Purpose of the Study:

To synthesize and evaluate novel cyclodextrin-based compounds for tabun detoxification.
To investigate the efficacy of these compounds under physiological conditions.

Main Methods:

Synthesis of cyclodextrin derivatives functionalized with hydroxamic acid-like moieties.
Assay of detoxification activity against tabun in TRIS-HCl buffer.
Kinetic analysis of detoxification reactions at physiological pH and temperature (37.0 °C).

Main Results:

The synthesized cyclodextrin compounds demonstrated significant efficacy in detoxifying tabun.
Detoxification half-times as low as 3 minutes were achieved.
The compounds function effectively at physiological pH and temperature.

Conclusions:

Hydroxamic acid-derived cyclodextrin compounds are potent agents for rapid tabun detoxification.
These findings present a promising strategy for developing countermeasures against organophosphate nerve agents.