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Ways in which SWL affects oxidant/antioxidant balance
Erdal Yilmaz1, Ahmet Haciislamoglu, Ucler Kisa
1Department of Urology, Faculty of Medicine, University of Kirikkale, Tip Fakultesi, Uroloji AD, Saglik Sokak, 71100, Kirikkale, Turkey. erdaly69@mynet.com
Extracorporeal shock wave lithotripsy (SWL) can cause kidney damage through oxidative stress. This study found SWL increases oxidative stress markers in urine, indicating an imbalance favoring oxidants after the procedure.
Area of Science:
- Nephrology
- Urology
- Biochemistry
Background:
- Kidney damage can occur after extracorporeal shock wave lithotripsy (SWL).
- Oxidative stress is a suspected cause of SWL-induced kidney damage.
- Evaluating oxidative stress markers in urine can assess kidney response to SWL.
Purpose of the Study:
- To assess the impact of SWL on kidney oxidative stress.
- To measure changes in urinary oxidative stress parameters before and after SWL.
- To determine if SWL disrupts the oxidant-antioxidant balance in kidney stone patients.
Main Methods:
- Included 20 kidney stone patients undergoing SWL.
- Measured 24-hour urine total antioxidant capacity (TAC) and total oxidant status (TOS) pre- and post-SWL.
- Calculated the oxidative stress index (OSI) from TAC and TOS values.
Main Results:
- Total oxidant status (TOS) significantly increased post-SWL (p = 0.006).
- Total antioxidant capacity (TAC) showed no significant change post-SWL (p = 0.312).
- Oxidative stress index (OSI) significantly increased post-SWL (p = 0.004), indicating a shift towards oxidative stress.
Conclusions:
- SWL application disrupts the oxidant-antioxidant balance, favoring oxidants and leading to oxidative stress.
- Urinary TOS, TAC, and OSI are potentially useful biomarkers for detecting post-SWL oxidative stress.
- These findings highlight the need to consider oxidative stress management in SWL procedures.
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