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Updated: May 13, 2026

Three-dimensional Optical-resolution Photoacoustic Microscopy
Published on: May 3, 2011
Handheld miniature probe integrating diffuse optical tomography with photoacoustic imaging through a MEMS scanning
Hao Yang1, Lei Xi, Sean Samuelson
1Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
Abstract:
We describe a novel dual-modality imaging approach that integrates diffuse optical tomography (DOT) and photoacoustic imaging (PAI) through a miniaturized handheld probe based on microelectromechanical systems (MEMS) scanning mirror. We validate this dual-modal DOT/PAI approach using extensive phantom experiments, and demonstrate its application for tumor imaging using tumor-bearing mice systematically injected with targeted contrast agents.
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