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Separation of non-collagenous proteins of bone formed in titanium implants: experimental study in the rabbit tibia,
1Department of Oral Biochemistry, Gothenburg University, Sweden.
Biomaterials
|April 1, 1990
Abstract:
The non-collagenous proteins of mature cortical rabbit bone and 3 wk old bone specimens formed in titanium implant bone harvest chambers, were separated by means of fine pressure liquid chromatography. It was found that a sufficient amount of bone could be obtained from five bone harvest chambers in five rabbits during a period of 15 wk. A different protein chromatographic pattern was found in bone grown in bone harvest chambers as compared to normal cortical bone from the same region. This indicates a difference in bone quality and shows that this implant design can be used for biochemical analysis of bone formed adjacent to a biomaterial.