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Published on: April 19, 2013
Vitamin D receptor gene polymorphisms and type 2 diabetes: a meta-analysis
1Department of Gastroenterology, Shandong Provincial Hospital, Shandong University, Jinan, China.
Background And Aims:
A number of studies have shown that polymorphisms in the vitamin D receptor (VDR) gene are implicated in susceptibility to type 2 diabetes (T2D). However, the results are inconsistent and inconclusive.
Methods:
A meta-analysis was performed to analyze the association among the four polymorphisms (FokI, BsmI, ApaI and TaqI) in the VDR gene and T2D susceptibility. A total of 14 articles were included in this meta-analysis.
Results:
FokI polymorphism was associated with an overall significantly increased risk of T2D (f vs. F: OR = 1.25, 95% CI = 1.10, 1.41; the extreme model ff vs. FF: OR = 1.48, 95% CI: 1.13, 1.94; the recessive model ff vs. Ff + FF: OR = 1.51, 95% CI = 1.25, 1.82). Subgroup analysis revealed a significant association between the Fok1 polymorphism and T2D in an Asian population.
Conclusions:
There was no between-study heterogeneity in any of these analyses. No significant associations were observed among the BsmI, ApaI and TaqI variants andT2D risk. This meta-analysis suggests that the FokI polymorphism of the VDR gene could be a risk factor for T2D, especially in an Asian population.
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