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Updated: May 13, 2026

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
09:38

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Adaptive designs for dual-agent phase I dose-escalation studies.

Jennifer A Harrington1, Graham M Wheeler, Michael J Sweeting

  • 1Department of Oncology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. jenny.harrington@cruk.cam.ac.uk

Nature Reviews. Clinical Oncology
|March 20, 2013
PubMed
Summary

Combining anticancer agents is key for curative cancer treatment. New adaptive designs can better explore drug interactions in dual-agent phase I trials, but require collaboration for successful implementation.

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