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Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Updated: May 13, 2026

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair

Published on: February 3, 2017

Current stem cell delivery methods for myocardial repair.

Calvin C Sheng¹, Li Zhou, Jijun Hao

¹School of Medicine, Vanderbilt University, 2220 Pierce Avenue, Nashville, TN 37232, USA.

Biomed Research International

|March 20, 2013

Summary

This summary is machine-generated.

Stem cell therapy shows promise for repairing heart damage from cardiovascular diseases. Research explores various cell types and delivery methods for myocardial regeneration, aiming for clinical viability.

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Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice

Ultrasound-Guided Induced Pluripotent Stem Cell-Derived Cardiomyocyte Implantation in Myocardial Infarcted Mice

Published on: March 30, 2022

Area of Science:

Regenerative Medicine
Cardiovascular Research

Background:

Cardiovascular diseases (CVDs) cause significant morbidity and mortality, often leading to irreparable heart failure.
Stem cell research offers potential novel therapies for reversing myocardial injuries.

Purpose of the Study:

To review stem cell types for myocardial repair.
To evaluate different cell delivery methods.
To assess the clinical feasibility, safety, and efficacy of stem cell therapy for heart failure.

Main Methods:

Investigated various stem cell types: embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), skeletal myoblasts, bone-marrow-derived stem cells (BMSCs), mesenchymal stem cells (MSCs), and cardiac stem cells (CSCs).
Explored diverse delivery approaches: intramyocardial, transendocardial, transcoronary, venous, intravenous, intracoronary artery, retrograde venous administrations, and bioengineered tissue transplantation.

Main Results:

Discussed the advantages and disadvantages of each delivery modality.
Evaluated the current therapeutic potentials of investigated stem cell types.
Presented a multifaceted assessment of reported clinical feasibility, safety, and efficacy.

Conclusions:

Optimal delivery approach, ideal stem cell type, effective dosage, and administration timing require further investigation.
Stem cell therapy is highly promising for myocardial regeneration and offers a potentially viable clinical option for heart failure treatment.