Obesogens and obesity--an alternative view?
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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
Published on: April 4, 2012
Richard M Sharpe1, Amanda J Drake
1MRC Centre for Reproductive Health, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK. r.sharpe@ed.ac.uk
Abstract:
It is accepted that diet is a major contributor to the obesity epidemic, but environmental 'obesogenic' chemicals have also been suggested recently as playing a role, based on in vitro, animal and epidemiological studies. Using two such 'obesogen' examples (bisphenol A, certain phthalate esters), we argue that their association with obesity and obesity-related disorders in humans could be circumstantial, and thus non-causal, because a Western style diet increases exposure to these compounds. This possibility needs to be addressed before further (confounded) epidemiological studies on 'obesogens' are undertaken.
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