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08:49
Rapid In Situ Hybridization using Oligonucleotide Probes on Paraformaldehyde-prefixed Brain of Rats with Serotonin Syndrome
Published on: September 23, 2015
Linezolid-induced serotonin syndrome
Vishal Gupta1, Niteen D Karnik, Rushikesh Deshpande
1Department of Medicine, Seth G Medical College and KEM Hospital, Mumbai, Maharashtra, India.
BMJ Case Reports
|March 21, 2013
Summary
Linezolid use in an organophosphorus poisoning patient with suspected infection may trigger serotonin syndrome. Prompt treatment with cyproheptadine and linezolid withdrawal led to recovery.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Clinical Toxicology
Background:
- Organophosphorus poisoning is a serious condition requiring intensive care.
- Nosocomial infections are a concern in critically ill patients, often treated empirically.
- Linezolid is an antibiotic used for Gram-positive bacterial infections.
Observation:
- A young drug abuser presented with organophosphorus poisoning and required mechanical ventilation.
- Empirical linezolid treatment was initiated for a suspected nosocomial infection.
- The patient subsequently developed high-grade fever, altered sensorium, and clonus.
Findings:
- Serotonin syndrome was suspected as a complication of linezolid therapy.
- Discontinuation of linezolid and administration of cyproheptadine resulted in clinical improvement.
- The patient recovered within three days of these interventions.
Implications:
- This case highlights a potential drug interaction between linezolid and organophosphorus poisoning.
- Clinicians should consider serotonin syndrome in patients on linezolid presenting with neurological symptoms.
- Early recognition and management with cyproheptadine are crucial for favorable outcomes.
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