Solitary circumscribed neuroma of the mucocutaneous eyelid margin

Solitary circumscribed neuroma (SCN), also known as a palisaded encapsulated neuroma, is characterised by a firm dome shape. These lesions are most commonly located in the head and neck regions near mucocutaneous junctions in adult patients. To date, SCN has rarely been reported on the eyelid. Clinically, these tumours present as slowly growing papules, often exhibiting a polypoid appearance. Histologically, they consist of Schwann cell and axon overgrowth and may be surrounded by a perineural capsule. Differential diagnosis should include other neural tumours associated with systemic conditions, such as neurofibromatosis and multiple endocrine neoplasia type 2b. In the presented case, the lesion was painless and histopathologic examination revealed a partially circumscribed, non-encapsulated dermal spindle cell proliferation, positive for S100. The tumour was successfully excised and there has been no evidence of recurrence to date. This represents a rare occurrence of SCN on the eyelid.