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Related Experiment Videos

[Autoimmune enteropathy causing protracted diarrhea].

Y Naveh1, Y Ben-Arieh, Z Greif

  • 1Dept. of Pediatrics B, Rambam Medical Center, Haifa.

Harefuah
|April 1, 1990
PubMed
Summary
This summary is machine-generated.

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This study reports the first case in Israel of intractable infantile diarrhea caused by autoantibodies targeting intestinal epithelium. The infant experienced severe, treatment-resistant diarrhea, highlighting a rare autoimmune condition.

Area of Science:

  • Pediatric Gastroenterology
  • Autoimmunology
  • Clinical Case Study

Background:

  • Protracted secretory diarrhea in infancy is a rare and challenging condition.
  • Autoimmune disorders can manifest in early childhood with diverse gastrointestinal symptoms.

Observation:

  • A 3-month-old infant presented with severe, intractable diarrhea since birth, unresponsive to standard therapies including total parenteral nutrition (TPN).
  • Family history revealed consanguinity and infant deaths from similar conditions.
  • Duodenal biopsy showed villous atrophy and lamina propria inflammation, with positive IgG autoantibodies against gut epithelium and thyroglobulin.

Findings:

  • The infant required prolonged TPN for 8 months due to feeding intolerance.
  • Complications included septicemia, osteomyelitis, and acute renal failure.

Related Experiment Videos

  • Postmortem examination confirmed near-complete intestinal villous flattening.

    • Implications:

    • This case represents the first documented instance in Israel of infantile diarrhea attributed to autoantibodies against intestinal epithelium.
    • The findings underscore the importance of considering autoimmune etiologies in refractory infantile diarrhea.
    • Early diagnosis and targeted immunomodulatory therapies may be crucial for managing such rare conditions.