Related Experiment Video
Updated: May 13, 2026

Synthesis and Assay of Vibrio Quorum Sensing Inhibitors
Published on: May 31, 2024
Drimendiol, a drimane sesquiterpene with quorum sensing inhibition activity
Cristian Paza1, Gerardo Cárcamo, Mario Silva
1Laboratory of Chemistry of Natural Products and Oceanographic Science, University of Concepción, Chile.
Abstract:
Quorum sensing (QS) is a regulatory mechanism that enables bacteria to make collective decisions such as an increase in virulence factors and biofilm production. Inhibitors of QS are important research tools in the discovery of new potential anti-bacterial agents. Polygodial, drimenol and drimendiol are drimane sesquiterpenoids isolated from Drimys winteri, a Chilean native tree. Their QS activity, when tested on Chromobacterium violaceum ATCC 12472, showed that drimendiol is an inhibitor of QS, decreasing violaceine production in C violaceum and decreasing biofilm formation of Pseudomonas syringae strains. Consequently it increased the biocide effects of CuSO4 on biofilms of P. syringae.
Related Concept Videos
Gene Regulation in Microbial Communities: Quorum Sensing
Antifungal Agents

