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Peripapillary choroidal neovascularization in pars planitis.

Sonia Mehta1, Luxme Hariharan, Allen C Ho

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Choroidal neovascularization (CNV) is a rare complication of intermediate uveitis. VEGF-inhibitor therapy effectively treated peripapillary CNV in a young patient, suggesting chronic disc edema as a potential risk factor.

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Uveitis Management

Background:

  • Choroidal neovascularization (CNV) is an uncommon complication associated with intermediate uveitis.
  • Risk factors for CNV in intermediate uveitis are not well-established.
  • This case report addresses peripapillary CNV in a patient with intermediate uveitis.

Purpose of the Study:

  • To describe a case of peripapillary CNV in a patient with intermediate uveitis.
  • To explore the pathophysiology of this condition.
  • To evaluate the treatment response to anti-VEGF therapy.

Main Methods:

  • Case report and literature review.
  • Patient presented with metamorphopsia, hemorrhage, and subretinal fluid.
  • Treatment involved intravitreal bevacizumab (1.25 mg) every 4 weeks for 4 months.

Main Results:

  • Fluorescein angiography confirmed active choroidal neovascular membrane.
  • Intravitreal bevacizumab led to resolution of hemorrhage and subretinal fluid.
  • Regression of CNV was observed with sustained inactivity of intermediate uveitis.

Conclusions:

  • Chronic disc edema may be a risk factor for peripapillary CNV in intermediate uveitis.
  • Vascular Endothelial Growth Factor (VEGF)-inhibitor therapy shows promise for treating peripapillary CNV.
  • Early intervention with anti-VEGF agents can lead to favorable outcomes.