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Updated: May 13, 2026

A Mouse Model of Fatigue Induced by Peripheral Irradiation
Published on: March 17, 2017
Fatigue in patients undergoing radiation therapy: an observational study
R Barbarino1, D Janniello, P Morelli
1Department of Diagnostic Imaging , Molecular Imaging, Interventional Radiology and Radiotherapy, Tor Vergata University General Hospital, Rome, Italy. sarabarbarino@katamail.com
This study found that a whey protein nutraceutical, Prother, effectively reduced fatigue in cancer patients undergoing radiation therapy. Prother improved treatment compliance and quality of life for patients with mild-to-moderate fatigue.
Area of Science:
- Oncology
- Nutrition Science
- Quality of Life Research
Background:
- Fatigue affects approximately 80% of patients undergoing radiation therapy, significantly diminishing their quality of life.
- Cancer-related fatigue is a prevalent and debilitating symptom impacting treatment adherence and overall well-being.
Purpose of the Study:
- To evaluate the efficacy of a specific nutraceutical (Prother) in managing fatigue.
- To assess changes in fatigue severity before, during, and after nutraceutical administration in breast and prostate cancer patients undergoing radiation therapy.
Main Methods:
- A study involving 30 cancer patients (20 breast, 10 prostate) who received a nutraceutical (Prother).
- Patients with moderate-to-mild fatigue (score 4-6 on MD Anderson Fatigue Scale) were given Prother (20g/day for 10 days, then 10g/day for 20 days).
- Fatigue levels were reassessed using the same scale after 10 and 30 days of nutraceutical administration; a control group of 30 patients did not receive Prother.
Main Results:
- The nutraceutical Prother demonstrated effectiveness in mitigating fatigue among all patients experiencing moderate-to-mild symptoms.
- Significant improvements in fatigue levels were observed in the group receiving the nutraceutical compared to the control group.
Conclusions:
- Administration of Prother was effective in improving the quality of life for cancer patients undergoing radiation therapy.
- Prother supplementation enhanced patient compliance with radiation treatment regimens.
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