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Streptococcus anginosus group and osteomyelitis: a single centre clinical experience
Allen Thomas Griffin1, Tristan Timbrook, Julie Harting
1Department of Medicine, Division of Infectious Diseases, University of Louisville, 501 East Broadway, Suite 380, Louisville, KY 40292, USA. atgrif01@louisville.edu
Postgraduate Medical Journal
|March 22, 2013
Summary
Osteomyelitis caused by the Streptococcus anginosus group is rare but aggressive. This study highlights the importance of prompt diagnosis and intensive treatment for these challenging infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Skeletal System Infections
Background:
- The Streptococcus anginosus group, part of the viridans streptococci, is recognized for causing abscesses and endocarditis.
- While implicated in various infections, osteomyelitis is an infrequent manifestation of Streptococcus anginosus group pathogens.
Purpose of the Study:
- To characterize the clinical features, demographics, comorbidities, and outcomes of patients with osteomyelitis caused by Streptococcus anginosus group bacteria.
- To investigate the unusual presentation of osteomyelitis attributed to S. anginosus group pathogens.
Main Methods:
- A retrospective review of a database was conducted to identify cases of osteomyelitis caused by S. anginosus group organisms.
- Data collected included patient demographics, comorbidities, infection site, route of infection (contiguous vs. hematogenous), laboratory findings, and clinical course.
Main Results:
- Eleven cases of S. anginosus group osteomyelitis were identified, predominantly contiguous in origin (10/11 cases).
- Common sites included foot (5 cases), mandible (3 cases), cranium (2 cases), and vertebrae (1 case).
- Abscesses were present in 75% of patients, with a mean antibiotic treatment duration of 10.9 weeks; treatment failure and relapse occurred in some patients.
Conclusions:
- Osteomyelitis due to the S. anginosus group is infrequently documented.
- This case series underscores the virulence of these bacteria in osteomyelitis and emphasizes the necessity for aggressive management strategies.
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