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Interaction between local anesthetics and analeptic drugs
Southern Medical Journal
|February 1, 1975
Summary
Local anesthetics like lidocaine may protect against seizures and reduce mortality when combined with analeptic drugs. This interaction, though clinically undesirable, shows protective effects in animal models, with lidocaine being most effective.
Area of Science:
- Pharmacology
- Neuroscience
- Toxicology
Background:
- Pharmacologic interactions between local anesthetics and analeptic drugs are often considered undesirable.
- However, potential protective effects of these interactions, particularly at high doses, warrant investigation.
Purpose of the Study:
- To investigate the protective effects of local anesthetic agents against seizures induced by analeptic drugs in mice.
- To evaluate the impact of different local anesthetics (procaine, lidocaine, tetracaine) on mortality when co-administered with analeptics (nikethamide, doxapram hydrochloride, pentylenetetrazol).
Main Methods:
- Mice were pretreated with procaine, lidocaine, or tetracaine.
- Convulsive doses of nikethamide, doxapram hydrochloride, or pentylenetetrazol were administered intraperitoneally.
- Incidence of seizures and mortality were recorded.
Main Results:
- Pretreatment with procaine, lidocaine, and tetracaine reduced seizure incidence when nikethamide or doxapram hydrochloride were administered.
- Mortality was decreased with nikethamide and was zero with doxapram hydrochloride.
- Lidocaine was the only agent that reduced mortality in pentylenetetrazol-treated mice, which all convulsed.
Conclusions:
- Clinically undesirable interactions between local anesthetics and analeptics can exhibit protective effects against seizures and mortality in mice.
- Lidocaine demonstrated the most significant protective effects among the tested local anesthetics, particularly against pentylenetetrazol-induced seizures.