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Updated: May 13, 2026

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
Published on: March 7, 2022
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the
Miriam Merad1, Priyanka Sathe, Julie Helft
1Department of Oncological Sciences, Mount Sinai Medical School, New York, NY 10029, USA. Miriam.merad@mssm.edu
Abstract:
Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.
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