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Gastric emptying and antral motility parameters in children with functional dyspepsia: association with symptom

Niranga Manjuri Devanarayana1, Shaman Rajindrajith, Madushanka S Perera

  • 1Department of Physiology, University of Kelaniya, Ragama, Sri Lanka. niranga1230@lycos.com

Journal of Gastroenterology and Hepatology
|March 23, 2013
PubMed

Insights

Children with functional dyspepsia (FD) exhibit impaired gastric emptying and antral motility. These gastric motility disturbances are linked to symptom severity, suggesting a key role in FD etiology for pediatric patients.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Motility Disorders
  • Functional Dyspepsia Research

Background:

  • Functional dyspepsia (FD) is a prevalent gastrointestinal disorder in children with unclear causes.
  • Abnormal gastric motility is a suspected contributor to FD symptoms.
  • This study investigates gastric motility in Sri Lankan children diagnosed with FD.

Purpose of the Study:

  • To evaluate gastric motility parameters in pediatric patients with functional dyspepsia.
  • To compare gastric emptying and antral motility between children with FD and healthy controls.
  • To explore the relationship between gastric motility and symptom severity in children with FD.

Main Methods:

  • Recruited 41 children meeting Rome III criteria for FD and 20 healthy controls.
  • Assessed liquid gastric emptying (GE) and antral motility using an ultrasound-based technique.
  • Measured fasting antral area, amplitude, and frequency of antral contractions.

Main Results:

  • Children with FD showed significantly reduced GE, antral contraction amplitude, and motility index compared to controls.
  • Fasting antral area was significantly higher in children with FD.
  • Abdominal pain severity negatively correlated with gastric emptying (r = -0.35, P = 0.025).
  • Stressful events were associated with increased fasting antral area in FD patients.

Conclusions:

  • Gastric emptying and antral motility are significantly impaired in children with FD.
  • Impaired gastric motility is a potential etiological factor for functional dyspepsia in pediatric populations.
  • Gastric motility disturbances correlate with symptom severity in children experiencing FD.
Abstract

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