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Physico-chemical characterisation of surface modified particles for inhalation
Katharina Stank1, Hartwig Steckel
1Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht University, Kiel, Germany. kstank@pharmazie.uni-kiel.de
International Journal of Pharmaceutics
|March 23, 2013
Summary
Co-milling micronised salbutamol sulphate with magnesium stearate or glycerol monostearate modifies particle surfaces. This surface modification improves aerosolisation and physical stability for inhalation drug products.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Surface modification of inhaled drugs is crucial for optimizing aerosol performance.
- Controlling interparticulate forces enhances drug delivery from inhalers.
- Micronised drugs often exhibit high cohesiveness, hindering effective aerosolisation.
Purpose of the Study:
- To investigate dry particle coating via co-milling for surface modification of inhaled drugs.
- To evaluate the impact of magnesium stearate (Mgst) and glycerol monostearate (GMS) on salbutamol sulphate (SBS) particle properties.
- To assess the influence of co-milling on aerosolisation and physical stability.
Main Methods:
- Micronised salbutamol sulphate (SBS) was blended with varying concentrations of Mgst or GMS.
- Blended powders underwent co-milling using an air jet mill.
- Characterization included SEM, EDX, laser diffraction, BET, and inverse gas chromatography.
- Co-milled samples were compared against physical mixtures.
Main Results:
- Co-milling resulted in a slight reduction in particle size.
- EDX confirmed Mgst deposition on SBS particles.
- Surface analysis revealed lowered dispersive surface energy and a more homogenous energy distribution for co-milled samples.
- Co-milling demonstrated superior surface modification compared to simple blending.
Conclusions:
- Co-milling is an effective dry particle coating technique for surface modification of inhaled pharmaceutical powders.
- Surface modification using Mgst or GMS via co-milling can enhance properties relevant to inhalation delivery.
- This method offers potential for improving aerosolisation and physical stability of suspension-based formulations.
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