Related Experiment Video
Updated: May 13, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
Psychosis and severe rhabdomyolysis associated with synthetic cannabinoid use: A case report
Dante Durand1, Leticia L Delgado1, Dhizarah Matus de la Parra-Pellot1
1University of Miami Miller School of Medicine, Miami, FL.
Background:
Synthetic cannabinoid (SC) or "spice" refers to a variety of herbal/chemical mixtures, which mimic the effects of marijuana. They are generally marked as "herbal incense" and best known by the brand names of "K2," "spice," "aroma," "Mr. Nice Guy" and "dream." Little data are available on the psychopathological and physical effects of SC.
Case Description:
We reported on a 23-year-old man without prior psychiatric history who developed acute psychosis and severe rhabdomyolysis (creatine phosphokinase [CPK]: 44,300 UI/L) associated with "Mr. Nice Guy" consumption. To our knowledge, this is the first case report of severe rhabdomyolysis associated with SC use in the U.S.
Conclusions:
Physicians should be aware of the possibility of new-onset psychotic symptoms and rhabdomyolysis in patients that use SC.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Psychosis: Goals of Pharmacotherapy
Psychosis and Antipsychotic Drugs: Overview
Drug toxicity: Idiosyncratic Reactions
Pharmaceutical Poisoning: Potential Scenarios

