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Precocious puberty following head injury. Case report
M Maxwell1, D Karacostas, R G Ellenbogen
1Neurosurgical Service, Massachusetts General Hospital, Brigham and Women's Hospital, Boston.
Journal of Neurosurgery
|July 1, 1990
Abstract:
A 6-year-old girl developed secondary sexual characteristics 5 months after severe closed head injury. Endocrinological tests confirmed a pubertal sexual condition; there was also diminution of serum melatonin and disruption of the diurnal pattern. Magnetic resonance imaging demonstrated focal hypothalamic injury; this is believed to be the first time such a posttraumatic lesion has been demonstrated by imaging techniques. The pathophysiology of this condition is discussed.