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Microdevices for nanomedicine.

Michinao Hashimoto¹, Rong Tong, Daniel S Kohane

¹Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

Molecular Pharmaceutics

|March 26, 2013

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Microdevices offer promising applications in nanomedicine for evaluating nanomaterial efficacy and toxicity. These miniaturized devices can mimic organ environments, potentially reducing animal testing in drug development.

Area of Science:

Biomedical Engineering
Nanotechnology
Pharmacology

Background:

Microdevices are miniaturized functional systems for cell/tissue handling or particle production.
Nanomedicine involves the application of nanotechnology to healthcare.
Current methods for nanomaterial evaluation have limitations.

Purpose of the Study:

To review manufacturing methods and applications of microdevices.
To discuss the relevance of microdevices to nanomedicine.
To highlight the potential of microdevices in nanomaterial research.

Main Methods:

Literature review of microdevice fabrication and applications.
Analysis of microdevice characteristics relevant to nanomedicine.
Discussion of microfluidics and microfabrication technologies.

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Main Results:

Microdevices enable rapid, low-cost evaluation of nanomaterial efficacy and toxicity.
Microdevices can mimic in vivo physiological environments, reducing reliance on animal models.
Microfabrication and microfluidics are key for nanomaterial synthesis and diagnostics.

Conclusions:

Microdevices show significant promise for advancing nanomedicine research.
The integration of microdevices in nanomedicine is still emerging but impactful.
Microdevices can enhance both fundamental and applied nanomedicine studies.