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Updated: May 13, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Association between esophageal leiomyomatosis and p53 mutation
Olga Kazarin1, Eugene Vlodavsky, Ludmilla Guralnik
1Department of Oncology, Rambam Health Care Campus and Technion-Israel Institute of Technology, Haifa, Israel.
Abstract:
Li-Fraumeni syndrome is a cancer predisposition syndrome associated with a variety of neoplasms, mainly soft tissue sarcoma, premenopausal breast cancer, brain tumors, adrenocortical carcinoma, and leukemia. Esophageal leiomyomatosis involves the presence of several rare benign neoplastic lesions composed of proliferating smooth muscle cells in the esophageal wall. The current case report presents a patient with recurrent diffuse leiomyomas of the esophagus and confirmed p53 mutation with clinical criteria of Li-Fraumenilike syndrome.
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