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Pediatric renal transplantation: results and prognostic factors

Po-Cheng Huang1, Ching-Yao Yang, Chih-Yuan Lee

  • 1Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Asian Journal of Surgery
|March 26, 2013
PubMed

Insights

Pediatric renal transplantation is a safe and effective treatment for end-stage renal disease, with acute rejection and male sex identified as key factors impacting graft survival in children.

Area of Science:

  • Pediatric Nephrology
  • Transplant Surgery
  • Immunology

Background:

  • End-stage renal disease (ESRD) significantly impacts children's quality of life.
  • Renal transplantation offers improved survival and quality of life for pediatric ESRD patients.

Purpose of the Study:

  • To investigate long-term outcomes of pediatric renal transplantation.
  • To identify prognostic factors influencing graft survival in pediatric kidney transplant recipients.

Main Methods:

  • Retrospective review of 25 pediatric renal transplantations (1995-2008).
  • Kaplan-Meier method for cumulative graft survival analysis.
  • Log rank tests and Cox regression for prognostic factor identification.

Main Results:

  • High graft survival rates: 92% at 12 months, 82.14% at 36 months.
  • Rejection-free survival rates of 88% (1 year) and 72.88% (3 years).
  • Acute rejection and male gender were significant negative prognostic factors for graft survival.

Conclusions:

  • Renal transplantation is a safe and effective procedure for pediatric ESRD.
  • Early identification and management of acute rejection are crucial.
  • Male gender is a significant risk factor for poorer graft outcomes in pediatric kidney transplants.
Abstract

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