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Updated: May 13, 2026
06:35
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
[Aortitis in giant cell arteritis and its complications]
1Service de médecine interne, pôle hospitalo-universitaire 3, centre de compétence maladies systémiques et auto-immunes rares, hôpital Hôtel-Dieu, CHU de Nantes, place Alexis-Ricordeau, 44093 Nantes cedex 01, France.
La Revue De Medecine Interne
|March 26, 2013
Summary
Aortitis, a complication of giant cell arteritis (GCA), increases risks of aortic aneurysm and dissection. Early screening via CT scans is recommended for GCA patients to detect aortitis and improve outcomes.
Area of Science:
- Vascular Inflammation
- Rheumatology
- Cardiovascular Imaging
Context:
- Aortitis is a severe complication of Giant Cell Arteritis (GCA).
- It poses risks of aortic aneurysm, rupture, and dissection.
- Aortitis prevalence may be underestimated, with subclinical cases detected by imaging.
Purpose:
- To highlight the significance of aortitis in GCA.
- To discuss diagnostic imaging modalities for aortitis.
- To recommend screening and further research.
Summary:
- Aortitis occurs in GCA patients, presenting at diagnosis or later, often as ascending aortic aneurysms.
- Imaging techniques like ultrasonography, PET, and CT scans reveal aortitis signs.
- Subclinical aortitis affects 20-65% of GCA patients, detected via imaging.
Impact:
- Aortitis detection at GCA diagnosis correlates with relapses and mortality.
- Screening GCA patients with aortic CT scans is advised.
- Further therapeutic trials are needed to improve aortitis management in GCA.
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