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Macrophage Differentiation and Polarization into an M2-Like Phenotype using a Human Monocyte-Like THP-1 Leukemia Cell Line
Published on: August 2, 2021
Macrophages: Good guys in colorectal cancer
Sofia Edin1, Maria L Wikberg, Per-Arne Oldenborg
1Department of Medical Biosciences, Pathology; Umeå University; Umeå, Sweden.
Oncoimmunology
|March 26, 2013
Abstract:
Macrophages play a complex role in tumor progression since they can exert both tumor-preventing (M1 macrophages) and tumor-promoting (M2 macrophages) activities. In colorectal carcinoma (CRC), at odds to many other cancers, macrophage infiltration has been correlated with an improved patient survival. In a recent study, we have evaluated the distribution of M1 and M2 macrophage subtypes in CRC and their impact on patient prognosis.
