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Glycan-based DC-SIGN targeting to enhance antigen cross-presentation in anticancer vaccines
Juan J García-Vallejo1, Wendy W J Unger, Hakan Kalay
1Department of Molecular Cell Biology and Immunology; VU University Medical Center; Amsterdam, The Netherlands.
Abstract:
In vivo dendritic-cell targeting constitutes a promising strategy for anticancer vaccination. Here, we discuss the usage of multivalent DC-SIGN-targeting glycan platforms that allow for the efficient routing of antigens to the endo-lysosomal pathway as well as to a yet uncharacterized cross-presentation mechanism inducing CD4+ and CD8+ T-cell responses.
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