Experimental actinomycetoma due to Nocardia transvalensis in laboratory mice

Nocardia transvalensis was investigated for its ability to cause mycetoma in the skin and foot pad of laboratory mice. Freund's incomplete adjuvant appeared to aid the development of mycetoma lesions. The infection manifested itself as palpable nodules under the skin which discharged white to cream coloured pus containing nocardial granules. The lesions in the skin necrotized, while those of foot pad resulted in bone destruction.