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How quantitative differences in dendritic cell maturation can direct TH1/TH2-cell polarization

Manfred B Lutz1

  • 1Institute of Virology and Immunobiology; University of Würzburg; Würzburg, Germany.

Oncoimmunology
|March 26, 2013
PubMed

The polarization of TH1 or TH2 responses by dendritic cells (DCs) requires distinct maturation conditions. Our data indicate that quantitative differences in DC maturation dictate a TH1 or TH2-cell polarization outcome. We discuss how chromatin remodeling at DC loci coding for pro-inflammatory vs. polarizing cytokines may explain differential TH-cell polarization.

Keywords:
HDACTH2chromatincytokinesdendritic cellsepigenetichistonepolarization

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