Related Experiment Video
Updated: May 13, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
Retinoic acid on stage in antitumor immunity
1Department of Microbiology and Immunology; The Geisel School of Medicine; Dartmouth University; Lebanon, NH USA.
Abstract:
The morphogenic role of retinoic acid (RA) in regulating immunity is underscored by our recent studies that show increased regional concentrations of RA and commensurate RA signaling in CD8+ T cells within the tumor microenvironment. This study demonstrated for the first time that intrinsic RA signaling is required for tumor associated antigen (TAA)-specific CD8+ T-cell survival and hence for tumor surveillance.
Related Concept Videos
Tumor Immunotherapy
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

