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Measuring Psoriasis Severity at Home
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Incidence of cardiovascular disease in individuals with psoriasis: a systematic review and meta-analysis

Eleanor J Samarasekera1, Julie M Neilson1, Richard B Warren2

  • 1National Clinical Guideline Centre, Royal College of Physicians of London, London, UK.

The Journal of Investigative Dermatology
|March 27, 2013
PubMed

Insights

Severe psoriasis significantly increases cardiovascular disease (CVD) risk, including mortality, myocardial infarction (MI), and stroke. This risk is highest in younger individuals with severe psoriasis.

Area of Science:

  • Dermatology and Cardiovascular Medicine

Background:

  • The link between psoriasis and cardiovascular disease (CVD) remains debated.
  • Psoriasis is an inflammatory condition with potential systemic effects.

Purpose of the Study:

  • To critically evaluate existing cohorts and meta-analyze the CVD risk associated with psoriasis.
  • To determine CVD risk based on psoriasis severity and age groups.

Main Methods:

  • Meta-analysis of 14 cohorts.
  • Analysis of primary outcomes: CVD mortality, stroke, and myocardial infarction (MI).
  • Subgroup analysis by psoriasis severity and age.

Main Results:

  • Increased CVD risk was observed exclusively in severe psoriasis patients.
  • Risk ratios for severe psoriasis: 1.37 for CVD mortality, 3.04 for MI, 1.59 for stroke.
  • Highest relative risks in younger severe psoriasis patients; greatest absolute risks in older severe psoriasis patients.

Conclusions:

  • Severe psoriasis is associated with a significantly elevated risk of cardiovascular events.
  • The risk is particularly pronounced in younger adults with severe disease.
  • Further research is needed to clarify the direct causal link and the role of traditional risk factors.

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