Selective serial multi-antibody biosensing with TOPAS microstructured polymer optical fibers
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Published on: January 25, 2012
Grigoriy Emiliyanov1, Poul E Høiby, Lars H Pedersen
1DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark. egrigoriy@hotmail.com
Abstract:
We have developed a fluorescence-based fiber-optical biosensor, which can selectively detect different antibodies in serial at preselected positions inside a single piece of fiber. The fiber is a microstructured polymer optical fiber fabricated from TOPAS cyclic olefin copolymer, which allows for UV activation of localized sensor layers inside the holes of the fiber. Serial fluorescence-based selective sensing of Cy3-labelled α-streptavidin and Cy5-labelled α-CRP antibodies is demonstrated.
