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Related Concept Videos

Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

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Related Experiment Video

Updated: May 12, 2026

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
03:53

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain

Published on: March 15, 2024

Neuropathic pain.

Allan Pollack1, Christopher Harrison, Joan Henderson

  • 1FMRC University of Sydney, New South Wales, Australia.

Australian Family Physician
|March 27, 2013
PubMed
Summary
This summary is machine-generated.

Neuropathic pain (NP), caused by nervous system damage, affects 7-8% of people in the UK and France. Further research is needed to understand its prevalence in Australia, where it may be underdiagnosed.

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Last Updated: May 12, 2026

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03:53

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Published on: March 15, 2024

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03:26

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Published on: March 8, 2024

Area of Science:

  • Neurology
  • Pain Medicine
  • Epidemiology

Background:

  • Neuropathic pain (NP) arises from somatosensory nervous system lesions or dysfunction.
  • Examples include diabetic polyneuropathy, postherpetic neuralgia, and spinal cord injury pain.
  • Existing prevalence data (7-8%) comes from the UK and France, with limited information for Australia.

Purpose of the Study:

  • To highlight the potential underdiagnosis of neuropathic pain in Australia.
  • To emphasize the need for epidemiological studies on NP prevalence in Australia.

Main Methods:

  • Review of existing literature on NP prevalence.
  • Analysis of diagnostic practices in Australia.

Main Results:

  • Neuropathic pain prevalence in Australia is not well-documented.
  • NP may be overlooked in Australia, often diagnosed as part of the underlying condition.

Conclusions:

  • There is a significant gap in understanding neuropathic pain prevalence in Australia.
  • Further epidemiological research is crucial to accurately assess the burden of NP in Australia.